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DC polarographic reduction of chloroguanide hydrochloride

✍ Scribed by F. Vicente-Pedrós; F. Tomás-Vert; J. Vera-Sánchez

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
333 KB
Volume
73
Category
Article
ISSN
0022-3549

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✦ Synopsis

0 Chloroguanide hydrochloride, an antimalarial drug, shows one well-defined DC polarographic wave in Britton-Robinson buffered media. In the pH range 3-9 the observed reduction wave is related to the reduction of the two azomethine centers on the monoprotonated biguanide group (BH+). The effects of pH and other experimental variables on the limiting current and half-wave potentials as well as the reduction mechanism arc discussed.

Keyphrases 0 Polarography-proguanil hydrochloride, effect of pH 0 Pronuanil hydrochloride-DC polarographic reduction

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