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DC activated via dectin-1 convert Treg into IL-17 producers

✍ Scribed by Fabiola Osorio; Salomé LeibundGut-Landmann; Matthias Lochner; Katharina Lahl; Tim Sparwasser; Gérard Eberl; Caetano Reis e Sousa

Book ID: 102164159
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 485 KB
Volume: 38
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.200838950

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## Abstract IL‐35 is a heterodimer of EBV‐induced gene 3 and of the p35 subunit of IL‐12, and recently identified as an inhibitory cytokine produced by natural Treg in mice, but not in humans. Here we demonstrate that DC activated by human rhinoviruses (R‐DC) induce IL‐35 production and release, as