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dbHCCvar: A comprehensive database of human genetic variations in hepatocellular carcinoma

✍ Scribed by Xiao-Jia Yu; Fang Fang; Chun-Lei Tang; Lei Yao; Lu Yu; Long Yu

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
715 KB
Volume
32
Category
Article
ISSN
1059-7794

No coin nor oath required. For personal study only.

✦ Synopsis

Hepatocellular carcinoma is a common cancer with a high mortality rate. The complete pathogenesis of hepatocellular carcinoma is not completely understood, and highly efficient therapy is still unavailable. In the past several decades, various genetic variations such as mutations and polymorphisms have been reported to be associated with hepatocellular carcinoma risk, progression, survival, and recurrence. However, to our knowledge, these genetic variations have not been comprehensively and systematically compiled. In this study we constructed dbHCCvar, a free online database of human genetic variations in hepatocellular carcinoma. Eligible publications were collected from PubMed, and detailed information and major research data from each eligible study were then extracted and recorded in our database. As a result, dbHCCvar contains almost all human genetic variations reported to be associated or not associated with hepatocellular carcinoma risk, clinical pathology, drug reaction, survival, or recurrence to date. It is expected that dbHCCvar will function as a useful tool for researchers to facilitate the search and identification of new genetic markers for hepatocellular carcinoma. dbHCCvar is free for all visitors at http://GenetMed.fudan.

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