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DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

✍ Scribed by Zannini, L.; Buscemi, G.; Kim, J.-E.; Fontanella, E.; Delia, D.

Book ID
121860386
Publisher
Chinese Electronic Periodical Services
Year
2012
Tongue
English
Weight
511 KB
Volume
4
Category
Article
ISSN
1673-520X

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ATM/ATR-like protein kinases play central roles in the maintenance of genome stability and phosphorylate numerous substrates in response to DNA damage, preferentially on SQ or TQ motifs. ATM/ATR substrates often contain several closely spaced SQ/TQ motifs in regions that have been termed SQ/TQ clust