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Daunomycin-immunoglobulin conjugates, uptake and activity in vitro

✍ Scribed by E. Hurwitz; R. Maron; R. Arnon; M. Wilchek; M. Sela


Book ID
113146132
Publisher
Elsevier Science
Year
1978
Weight
681 KB
Volume
14
Category
Article
ISSN
0014-2964

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## Abstract As an approach to developing more specific anti‐tumour therapeutic agents, daunomycin has been covalently linked to the human tumour localizing, murine monoclonal antibody 79IT/36. Four procedures for coupling drug to antibody were investigated. The sugar amino group of daunomycin was m