✦ LIBER ✦

Dating gallstones

✍ Scribed by David F. Ransohoff

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 260 KB
Volume: 7
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840070236

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✦ Synopsis

HEPATOLOGY ELSEWHERE

401

(9), no evidence was found recently for either su1fate:bile acid exchange (10) or bicarbonate:bile acid exchange (11) at the canalicular membrane surface.

Thus, at present, the movement of bile acid anions out of the hepatocyte appears to be the result of carriermediated, facilitated diffusion, favored by the negative intracellular electrical potential. However, based on the Nernst equation, this cannot be the sole process by which bile acids are concentrated into bile (5), and the contribution of exocytosis of vesicle-associated bile acids derived from the endoplasmic reticulum and Golgi apparatus and/or other carrier-mediated transport mechanisms remain to be determined. Perhaps additional studies, currently underway, using both liver plasma membrane vesicles and isolated hepatocyte couplets (12), with a defined canalicular space ideally suited for micropuncture, will clarify hepatic bile acid transport to the same degree as Weinberg and colleagues have for the intestinal transport of these important organic anions.

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