Data Smoothing Effects on the Abel Inversion Method in Plasma Spectroscopy

The effect of competitive and non-linear

The effect of competitive and non-linear plasma protein binding on the stereoselective disposition and metabolic inversion of ibuprofen in healthy subjects

✍ David E. Smith; Jyoti K. Paliwal; Steven R. Cox; Rosemary R. Berardi; Valerie A. 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 806 KB

The stereoselective disposition and metabolic inversion of ibuprofen were studied in 12 healthy subjects under conditions of competitive and non-linear plasma protein binding. Each subject received each of four oral treatments according to a Latin-square design: 300 mg R( -)-ibuprofen, 300 mg S( +)-