Data Preprocessing of In Situ Laser-Backscattering Measurements

✍ Scribed by J. Heinrich; T. Elter; J. Ulrich

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 381 KB
• Volume: 34
• Category: Article
• ISSN: 0930-7516
• DOI: 10.1002/ceat.201000238

✦ Synopsis

Abstract

In situ measurement techniques are promising tools to aid process development. However, they also pose new challenges in evaluating large amounts of recorded data. A new procedure for in situ laser‐backscattering devices has been developed that allows transformation of the raw recorded data, a chord length distribution, into a format suitable for population balance modeling. Emphasis is thereby laid on the influence of the suspension density on the measured data. Experimental data are recorded using a batch laboratory crystallizer equipped with an in situ 3D‐ORM laser backscattering device and an ultrasound probe. The new proposed five‐step procedure for data preprocessing is based on several independently developed tools from literature and is exemplarily illustrated with results on the crystallization of ascorbic acid. The proposed method is a step forward to use in situ laser‐backscattering devices also for quantitative purposes.