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Dasatinib therapy for systemic mastocytosis: four cases

✍ Scribed by Duncan Purtill; Julian Cooney; Raja Sinniah; Ben Carnley; Gavin Cull; Bradley Augustson; Paul Cannell


Book ID
114794379
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
61 KB
Volume
80
Category
Article
ISSN
0902-4441

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Phase II study of imatinib mesylate as t
✍ Arturo Vega-Ruiz; Jorge E. Cortes; Matjaz Sever; Taghi Manshouri; Alfonso QuintΓ‘ πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 English βš– 375 KB

Gain-of-function D816V point mutation within the kinase domain of the transmembrane receptor KIT is found in the great majority of patients with systemic mastocytosis (SM) and is attractive therapeutic target. Twenty patients with SM were enrolled during 2003-2005 in phase II clinical trial with ima