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Dasatinib, a Novel Abl-Src Kinase Inhibitor, in the Management of Patients with Philadelphia Chromosome–Positive Leukemias

✍ Scribed by Mughal, Tariq I.


Book ID
122396361
Publisher
CIG Media Group, LP.
Year
2006
Tongue
English
Weight
105 KB
Volume
1
Category
Article
ISSN
1931-6925

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The molecular basis of the Philadelphia chromosome (Ph') is a structurally altered c-abl (bcr-abl) gene which encodes an abnormally large protein with protein tyrosine kinase activity. Herbimycin A, which effectively reduced intracellular phosphorylation by bcr-abl tyrosine kinase, preferentially in