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Das Syndrom der „unangemessenen” Antidiuretinsekretion und die Ausscheidung von Aldosteron im Harn

✍ Scribed by Šolc, J.


Publisher
Springer-Verlag
Year
1975
Weight
455 KB
Volume
120
Category
Article
ISSN
0044-2917

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✦ Synopsis


The syndrome of inappropriate ADI-I secretion was diagnosed on the basis of the cardinal features described by Bartter and Schwartz in 3 patients: one neonate with bacterial meningitis and two children respectively under Vincristin and Cyclophosphamide treatment. Treatment with fluid restriction and infusions of hypertonic saline led to a slow excretion of the water excess and to the restoration of both the body fluid volume and serum sodium coneentration. The urinary excretion of aldosterone was found to be in the normal range or slightly increased during the development of the syndrome and at the beginning of the therapy. In the phase of recovery there was decreased urinary aldosterone.


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The effect of intravenous aldosterone on the glomerular filtration rate and urinary excretion of sodium and potassium was evaluated in 12 newborns (aged 7 to 21 days) and 12 infants (aged 2 to 12 months). A decrease in sodium excretion was demonstrated in the latter group only. There was a decreased