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DARPP-32 Promotes TRAIL Resistance Through Regulation of BCL-XL in Gastric Cancer Cells

✍ Scribed by Belkhiri, Abbes ;Mehio, Suhayl M. ;Zhu, Shoum ;El-Rifai, Wael

Book ID
122150722
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
37 KB
Volume
140
Category
Article
ISSN
0016-5085

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Recent studies have shown that high levels of the apoptosisrelated proteins bcl-2 and bcl-x, increase, while over-expression of bcl-x, or bax decreases, resistance to drugs that induce apoptosis in some human cancer cells. In the present report, we investigated whether expression of these apoptosis-