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Dark adaptation compared with electrooculography in primary biliary cirrhosis

✍ Scribed by C. Barber; G. Brimlow; N. R. Galloway; P. Toghill; R. P. Walt

Book ID
104644835
Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
224 KB
Volume
71
Category
Article
ISSN
0012-4486

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✦ Synopsis

In a series of asymptomatic patients with primary biliary cirrhosis there was a significant impairment of dark adaptation thresholds as compared with a control group. Vitamin A levels were abnormally low in only two of the patients and these two both showed high dark adaptation thresholds. The electrooculogram was reduced in only the most severely affected case. It is suggested that visual function tests should be performed alongside vitamin A level measurements before deciding on treatment.

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An impaired sulfoxidation pathway has been implicated in the pathogenesis of chlorpromazineinduced hepatotoxicity. Since some patients with chronic chlorpromazine-induced cholestasis may have features of primary biliary cirrhosis, we studied the ability to sulfoxidate the amino acid analogue 5'-carb