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Dapsone induced methemoglobinemia in a patient with glioblastoma

✍ Scribed by Julie G. Walker; Tapan Kadia; Latrondria Brown; Harinder S. Juneja; John F. de Groot

Publisher
Springer US
Year
2009
Tongue
English
Weight
175 KB
Volume
94
Category
Article
ISSN
0167-594X

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Dapsone-induced methemoglobinemia : A do
Dapsone-induced methemoglobinemia : A dose-related occurrence?
✍ Adam J. Esbenshade; Richard H. Ho; Ayumi Shintani; Zhiguo Zhao; Lesley-Ann Smith πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 144 KB

## Abstract ## BACKGROUND: Dapsone, used for __Pneumocystis jiroveci__ (PCP) prophylaxis, is associated with increased risk of methemoglobinemia. Absence of cytochrome b5 reductase enzyme activity causes congenital methemoglobinemia, but its role in dapsone‐associated methemoglobinemia is unknown.

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Dapsone, a sulfone antibiotic, has been increasingly used in solid-organ transplant recipients for the primary prevention of Pneumocystis carinii pneumonia, especially in patients with documented sulfa allergy. A known side effect of dapsone therapy, however, is methemoglobinemia, a condition leadin