Dantrolene can reduce secondary damage after spinal cord injury
β Scribed by Adem Aslan; Mustafa Cemek; Mehmet Emin Buyukokuroglu; Korhan Altunbas; Orhan Bas; Yusuf Yurumez; Murat Cosar
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 368 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0940-6719
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π SIMILAR VOLUMES
## Abstract We examined the efficacy of FK506 in reducing tissue damage after spinal cord injury in comparison to methylprednisolone (MP) treatment. Rats were subjected to a photochemical injury (T8) and were given a bolus of MP (30 mg/kg), FK506 (2 mg/kg), or saline. An additional group received a
After spinal cord injury (SCI), a complex cascade of pathophysiological processes increases the primary damage. The inflammatory response plays a key role in this pathology. Recent evidence suggests that myeloperoxidase (MPO), an enzyme produced and released by neutrophils, is of special importance