Dammarane Derivatives Protect Cultured Rat Cortical Cells from Glutamate-induced Neurotoxicity
β Scribed by SO RA KIM; SANG HYUN SUNG; SUNG WON KWON; JEONG HILL PARK; HOON HUH; YOUNG CHOONG KIM
- Book ID
- 111768581
- Publisher
- Pharmaceutical Press
- Year
- 2000
- Tongue
- English
- Weight
- 82 KB
- Volume
- 52
- Category
- Article
- ISSN
- 2042-7158
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Certain natural products and Asian herbal remedies have been used in Asia to attenuate neurodegenerative diseases, including senile dementia. We have examined derivatives of several natural products for potential neuroprotective activity in an in vitro test system. In the present study, we assayed a
## Abstract In previous work, we isolated 7 neuroprotective iridoid glycosides from the 90% MeOH fraction of __Scrophularia buergeriana__ (Scrophulariaceae). We therefore investigated the mode of action of 8β__OβEβp__βmethoxycinnamoylβharpagide (8βMCAβHarp), the most potent neuroprotective iridoid,