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Dacarbazine (DTIC), human recombinant interferon alpha 2a (Roferon) and 5-fluorouracil for disseminated malignant melanoma

✍ Scribed by Mulder, NH; de Vries, EGE; Sleijfer, DTh; Schraffordt Koops, H; Willemse, PH


Book ID
109836817
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
308 KB
Volume
65
Category
Article
ISSN
0007-0920

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Preclinical data suggest synergy of interleukin-2 (IL-2) combined with alphainterferon (IFN). In addition, toxicities of IL-2 may be decreased by intermittent continuous infusion. The purpose of this trial was to determine the maximum tolerated dose (MTD) of recombinant IL-2 combined with alpha-IFN