𝔖 Bobbio Scriptorium
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D25 - Inclusion of “nonhypertensive” subjects in antihypertensive drug studies

✍ Scribed by SJ Rosansky; SJ Menachery; C Marshall


Book ID
116156221
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
186 KB
Volume
8
Category
Article
ISSN
0895-7061

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## Abstract Two methods have been developed for the introduction of deuterium into the doxepin molecule. The key intermediate (6,11‐dihydro‐1,2,3,4‐^2^H~4~‐dibenz[b,e]oxepin‐11‐one, 5) was prepared by condensation of ethyl 2‐bromomethylbenzoate with [^2^H~6~]‐phenol, saponification of the resulting