D2 and 5-HT2 modulation of psychostimulant-induced facilitation of brain stimulation reward

✍ Scribed by Vladimir Tsibulsky; Boris Dashevsky; Robert A. Frank

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 778 KB
• Volume: 34
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430340307

✦ Synopsis

Abstract

Previous research in our laboratory demonstrated that mixed D~2~/5‐HT~2~ antagonists (i.e., MDL 28, 133A, and risperidone) attenuate both amphetamine and cocaine‐induced facilitation of brain stimulation reward. The relative contributions of dopaminergic and serotonergic antagonism to these effects was assessed in the present study. Factorial combinations of the D~2~ antagonist eticlopride and the 5‐HT~2~ antagonist MDL 100,907 were evaluated for their ability to reverse both cocaine and amphetamine‐induced facilitation of brain stimulation reward. Eticlopride significantly reduced the effects of both amphetamine and cocaine, while MDL 100,907 had no effect on self‐stimulation thresholds when administered alone, or in combination with eticlopride. Thus, no evidence for serotonergic regulation of the euphoric effects of psychostimulants was obtained. © 1995 Wiley‐Liss, Inc.