✦ LIBER ✦

D1 dopamine receptors mediate neuroleptic-induced Fos expression in the islands of Calleja

✍ Scribed by David Wirtshafter

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 158 KB
Volume: 28
Category: Article
ISSN: 0887-4476
DOI: 10.1002/(sici)1098-2396(199802)28:2<154::aid-syn5>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

Systemic injections of the selective, full, D 1 agonists A-77636 and SKF-82958 induced pronounced Fos-like immunoreactivity in the islands of Calleja in the olfactory tubercle of intact rats. Fos expression in this region could also be induced by injections of the D 2 -like dopamine antagonist raclopride (0.5 mg/kg). Pretreatment with the selective D 1 dopamine antagonist SCH-23390 (0.2 mg/kg) completely abolished this response, but was without significant effect on raclopride-induced Fos expression in the dorsolateral region of the striatum. SCH-23390 was also able to prevent the atypical neuroleptic clozapine (30 mg/kg) from inducing Fos expression in the islands of Calleja. These findings demonstrate that stimulation of D 1 dopamine receptors plays an essential role in neuroleptic induction of Fos-like immunoreactivity in the islands of Calleja, but not in the dorsal striatum, and thus suggest that different mechanisms underlie neuroleptic stimulation of immediate early gene expression in these two structures.

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