d -Galactofuranosylphosphonates. First Synthesis of UDP- C - d -galactofuranose
✍ Scribed by Kovensky, José; McNeil, Michael; Sinaÿ, Pierre
- Book ID
- 126163133
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 86 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3263
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## Abstract Galactofuranose metabolism is a good target for the development of novel chemotherapeutic agents for the treatment of some microbial infections. This is a valid objective because galactofuranose is absent in mammals. Two enzymes are involved in the biosynthesis of molecules containing g
ABSTRACr 5-0-Methyl-D-galactofuranose (7) was synthesized, for the first time, in five steps from D-galactono-1,4-lactone (1) in good overall yield. Tritylation and further acetylation of 1 gave 2,3,5-tri-O-acetyl-6-O-trityl-D-galactono-l,Clactone (2); prolonged acetylation caused elimination to for