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D- and T-optimum designs for the kinetics of a reversible chemical reaction

✍ Scribed by Anthony C. Atkinson; Barbara Bogacka; Mariusz B. Bogacki

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
295 KB
Volume
43
Category
Article
ISSN
0169-7439

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Alprazolam underwent a facile 1,4-benzodiazepine ring-opening reaction in an acidic aqueous solution to form a benzophenone compound. The reaction was demonstrated by means of UV, IR, and 1H- and 13C-NMR spectroscopy. Its reverse cyclization reaction to alprazolam occurred when an acidic solution wa