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[D-ALA2]deltorphin II analogs with high affinity and selectivity for delta-opioid receptor

✍ Scribed by Yusuke Sasaki; Akihiro Ambo; Kenji Suzuki

Book ID
117055366
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
287 KB
Volume
180
Category
Article
ISSN
0006-291X

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## Abstract Delta opioid receptor (DOR) mRNA levels were studied in mice rendered tolerant to [D‐Ala^2^]deltorphin II by 4 days of repeated intracerebroventricular administration (10ΞΌg, [tid]). ED~50~ determinations on day 5 revealed a 10‐fold loss in [D‐Ala^2^]deltorphin II potency with the tail‐f