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D-23129: A New Anticonvulsant Compound

✍ Scribed by Izet M. Kapetanovic; Chris Rundfeldt

Book ID
109105411
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
750 KB
Volume
2
Category
Article
ISSN
1080-563X

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The anticonvulsant activity of the novel drug D-23129 (N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester) was evaluated in animal models of epileptic seizures. D-23129 was active after oral and intraperitoneal administration in rats and mice in a range of anticonvulsant tests at non

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D-23129 [N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester] and D-20443 (dihydrochloride of D-23129) are promising anticonvulsant compounds with a broad spectrum activity in animal models of epilepsy. Their effects on de novo synthesis of excitatory (glutamate and aspartate) and inh