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Cytotoxicity of metronidazole (Flagyl) and misonidazole (Ro-07-0582): enhancement by lactate

โœ Scribed by Mahood, J S; Willson, R L


Book ID
109835276
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
648 KB
Volume
43
Category
Article
ISSN
0007-0920

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The hypoxic cell radiosensitizer 2-[14C] misonidazole: 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol (Ro 07-0582) MISO was administered to mice, control rats, and rats bearing chemically induced rhadbdomyosarcoma. The dose injected was 250 mg/kg and the delivered activity was 100 microCi/kg. Whole-b