Cytotoxicity of commonly used solvents at elevated temperatures

✍ Scribed by Gloria C. Li; George M. Hahn; Esther C. Shiu

• Book ID: 102309306
• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 318 KB
• Volume: 93
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040930303

✦ Synopsis

Abstract

At 43°C (but not at 41°C), organic solvents used to dissolve water‐insoluble chemotherapeutic agents become themselves lethal to cells. This finding is not unique to Chinese hamster cells (HA‐1); mouse mammary sarcoma cells (EMT‐6) behave similarly. The solvent concentrations involved are in the range of those needed to make drug solutions. Hence experiments measuring drug‐cell interactions at elevated temperatures must include controls which independently measure solvent effects.