𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cytotoxicity of Anti-CD64-Ricin A Chain Immunotoxin Against Human Acute Myeloid Leukemia Cells In Vitro and in SCID Mice

✍ Scribed by Zhong, R.K.; van de Winkel, J.G.J.; Thepen, T.; Schultz, L.D.; Ball, E.D.


Book ID
120443309
Publisher
Mary Ann Liebert
Year
2001
Tongue
English
Weight
349 KB
Volume
10
Category
Article
ISSN
1061-6128

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Potent anti-tumor effects of an anti-CD2
✍ Roland Schnell; Ali A. Katouzi; Christoph Linnartz; Gisela Schoen; Silke Drillic 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 859 KB

A new anti-CD24 immunotoxin (IT), SWAl l.dgA, was constructed by coupling the MAb SWAl I via the bivalent linker SMPT to deglycosylated r i c h A-chain (dgA). The effects of SWAl I .dgA were evaluated in vitro against the B-precursor leukemia cell line REH, the non-6-non-T acute lymphoblastic leukem

Immunotoxins constructed with anti-CD25
✍ Andreas Engert; Gary Martin; Peter Amlot; John Wijdenes; Volker Diehl; Philip Th 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 867 KB

## Abstract Twenty‐three monoclonal antibodies (MAbs) against the IL‐2 receptor α‐chain (CD25) were evaluated as ricin A‐chain immunotoxins for the treatment of Hodgkin's disease. Primary screening used an indirect assay in which the cells were treated with the test antibody followed by a Fab immun

In vivo efficacy of the recombinant anti
✍ Mehmet Kemal Tur; Michael Huhn; Edgar Jost; Theo Thepen; Tim H. Brümmendorf; Ste 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 533 KB

## Abstract Target‐specific acute myeloid leukemia (AML) immunotherapy requires selective cell‐surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full‐lengt

Cocktails of ricin a-chain immunotoxins
✍ Andreas Engert; Claudia Gottstein; Heribert Bohlen; Ute Winkler; Gisela Schön; O 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 645 KB

Three ricin A-chain immunotoxins (ITS) recognizing different antigens on Hodgkin-Reed/Sternberg (H-RS) cells were evaluated for their anti-tumor effects when used in combination as "cocktails". These ITS, 66 I0.dgA (CD25). HRS3.dgA (CD30). and IRac.dgA (70 kDa), strongly inhibited the growth of L54O

Evaluation of four CD22 antibodies as ri
✍ Guo-Liang Shen; Jia-Ling Li; Maria-Ana Ghetie; Victor Ghetie; Richard D. May; Ma 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 668 KB

Ricin A chain-containing immunotoxins (IT-As) specific for the human &ell antigen, CD22, were prepared from 4 monoclonal antibodies (MAbs) or their Fab' fragments: RFB4, HD6, UV22-I and UV22-2. The ITS were tested for their ability to kill cells from the Burkitt lymphoma line, Daudi, the pre-6cell l