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Cytotoxicity of a transferrin-adriamycin conjugate to anthracycline-resistant cells

✍ Scribed by Monika Fritzer; Klara Barabas; Viktoria Szüts; Alajos Berczi; Thomas Szekeres; W Page Faulk; Hans Goldenberg

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 461 KB
Volume: 52
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910520421

No coin nor oath required. For personal study only.

✦ Synopsis

Conjugates of adriamycin coupled to transferrin byglutaraldehyde are cytotoxic to human promyelocytic (HL-60) and erythroleukemic (K562) cells. Growth inhibition of adriamycinsensitive cells, as evaluated by thymidine incorporation and the MlT-assay, was higher for conjugates than for free adriamycin. The cytotoxicity toward adriamycin-resistant K562 and HL-60 cells was 3-fold and more than 10-fold higher, respectively, for the transferrin-adriamycin conjugate than for the free drug. The effect of the conjugate was dependent on its adriamycin content, i.e., on its conjugation number.

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