𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cytotoxicity and genotoxicity of capsaicin in human neuroblastoma cells SHSY-5Y

✍ Scribed by François Richeux; Marta Cascante; Rachid Ennamany; Dominique Saboureau; Edmond Ekué Creppy

Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
346 KB
Volume
73
Category
Article
ISSN
0340-5761

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Un-nicked BoNT/B activity in human SHSY-
Un-nicked BoNT/B activity in human SHSY-5Y neuronal cells
✍ Xuerong Shi; Gregory E. Garcia; Madhusoodana P. Nambiar; Richard K. Gordon 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB 👁 1 views

## Abstract BoNT/B holotoxin (HT) from the native source is a mixture of nicked and un‐nicked forms. A previous study showed that while un‐nicked HT could be transcytosed by intestinal epithelial cells, they did not correlate this with proteolytic activity or biological effect(s). Un‐nicked HT is l

TCEP treatment reduces proteolytic activ
TCEP treatment reduces proteolytic activity of BoNT/B in human neuronal SHSY-5Y cells
✍ Xuerong Shi; Gregory E. Garcia; Roger J. Neill; Richard K. Gordon 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 296 KB 👁 1 views

## Abstract The light chain (LC) of botulinum neurotoxin B (BoNT/B) is unable to enter target neuronal cells by itself. It is brought into the cell in association with the BoNT/B heavy chain (HC) through endocytosis. The BoNT HC‐LC subunits are held together by a single disulfide bond. Intracellula

The biological activity of ubiquitinated
The biological activity of ubiquitinated BoNT/B light chain in vitro and in human SHSY-5Y neuronal cells
✍ Xuerong Shi; Jennifer E. Curran; Zhilin Liao; Richard K. Gordon 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB 👁 1 views

## Abstract BoNT/B light chain is a zinc‐dependent endopeptidase. After entering its target, the neuronal cell, BoNT/B is responsible for synaptobrevin‐2 (VAMP‐2) cleavage. This results in reduced neurotransmitter (acetylcholine) release from synaptic vesicles, yielding muscular paralysis. Since th

Cytotoxicity, differentiating activity a
Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells
✍ Konrad Pillwein; Katharina Schuchter; Gabi Ressmann; Kamran Gharehbaghi; Andreas 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 572 KB

## Abstract The IMP dehydrogenase inhibitor, tiazofurin (TR)‐2‐β‐D‐ribofuranosylthiazole‐4‐carboxamide, which exhibited oncolytic activity in patients with chronic myelogenous leukaemia (CML) in blast crisis was found to inhibit the growth of human neuroblastoma SK‐N‐SH cells with an IC~50~ of 4.2