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Cytotoxicity and cellular uptake of tri-block copolymer nanoparticles with different size and surface characteristics

✍ Scribed by Sourav Bhattacharjee, Dmitry Ershov, Kleanthis Fytianos, Jasper van der Gucht, Gerrit M Alink, Ivonne M C M Rietjens, Antonius T M Marcelis, Han Zuilhof

Book ID: 119909039
Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 997 KB
Volume: 9
Category: Article
ISSN: 1743-8977
DOI: 10.1186/1743-8977-9-11

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## Abstract The cellular uptake of DNA block copolymer micelles composed of DNA‐__b__‐PPO in Caco‐2 cells was studied. In particular it was investigated if the shape of micelle aggregates influences the internalization. Rod‐like polymeric particles were taken up 12 times more efficiently than their