Cytotoxicity and arecoline mechanisms in human gingival fibroblasts in vitro
β Scribed by Yu-Chao Chang; Chao-Chin Hu; Chong-Kuei Lii; Kuo-Wei Tai; Shyh-Hwang Yang; Ming-Yung Chou
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 119 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1432-6981
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Arecoline, an active alkaloid of Areca catechu L., and sodium nitrite, a food additive, are highly cytotoxic and cytostatic on the Hep 2 cell line when administered in an acidic environment (pH 4.2) in the presence of S-9 mixture. Hep 2 cells (10(6)) were treated with either 0.145, 0.725 or 1.449 mM