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Cytotoxic Triterpenoid Saponins Acetylated with Monoterpenoid Acid from Albizia julibrissin

✍ Scribed by Kun Zou; Qing-Ying Zhang; Bin Wang; Jing-Rong Cui; Yu-Ying Zhao; Ru-Yi Zhang

Publisher: John Wiley and Sons
Year: 2010
Tongue: German
Weight: 180 KB
Volume: 93
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201000059

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✦ Synopsis

Abstract

Three new triterpenoid saponins, named julibroside J~16~ (2), julibroside J~17~ (3), and julibroside J~21~ (4), each of which possesses an oleanane triterpenoid aglycone of acacic acid, two monoterpenoid acids, and nine sugar moieties, together with one known saponin, julibroside II (1), were isolated from the stem bark of Albizia julibrissin by chromatographic methods. Their structures were established by chemical and spectroscopic means. Saponins 1, 2, and 4 showed inhibitory activities against Bel 7402 human cancer cell line in vitro.

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## Abstract Four new triterpenoidal saponins acylated with monoterpenic acid, __i.e.__, adianthifoliosides C, D, E, and F (**1**–**4**), besides the two known julibroside III and the monodesmonoterpenyl elliptoside A, were isolated from the roots of __Albizia adianthifolia.__ Their structures were