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Cytotoxic T lymphocyte antigen-4 promoter −658CT gene polymorphism is associated with ulcerative colitis in Chinese patients

✍ Scribed by Yan Luo; Bing Xia; Chun Li; Zhitao Chen; Liuqing Ge; Ting Jiang; Feng Zhou; Yan Zhao


Publisher
Springer
Year
2008
Tongue
English
Weight
165 KB
Volume
24
Category
Article
ISSN
0179-1958

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The CTLA-4 gene encodes a T-cell receptor that is involved in the regulation of T-cell activation. Recent studies have demonstrated an association of a microsatellite polymorphism [variant lengths of a dinucleotide (AT)n repeat] lying in exon 3 of the CTLA-4 gene, specifically a 106-bp allele, with