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Cytotoxic T cells transduced with chimeric anti-CD19 receptors prevent engraftment of primary lymphoblastic leukemia in vivo

✍ Scribed by Landmeier, S; Altvater, B; Pscherer, S; Meltzer, J; Sebire, N; Pule, M; Vera, J; Hotfilder, M; Juergens, H; Vormoor, J


Book ID
109887367
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
343 KB
Volume
24
Category
Article
ISSN
0887-6924

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## Abstract CD19 is an attractive therapeutic target for treating human B‐cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37‐DcVV) anti‐CD19 monoclonal antibodies (MAbs) were constructed, expressed and evaluated for their binding to human 19‐positive (CD19^+^) tumor cel