## Potentiation of immunogenicity of malignant cells by gene transduction provides a unique opportunity for immune targeting of human cancers in vivo. This approach is undoubtedly influenced by the ability of the malignant cells to process and present endogenously target epitopes on their cell surf
โฆ LIBER โฆ
Cytotoxic T cell recognition of a human melanoma derived peptide with a carboxyl-terminal alanine-proline sequence
โ Scribed by Naoko Morioka; Yoshikazu Kikumoto; Dave S.B. Hoon; Donald L. Morton; Reiko F. Irie
- Book ID
- 116097614
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 1010 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0161-5890
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The human melanocyte lineage-specific antigen gp100 contains several epitopes recognized by cytotoxic T lymphocytes (CTL). However, most of the epitopes reported to date are HLA-A2.1-restricted. Despite the high frequency of HLA-A2.1 in melanoma patients, effective population coverage requires the i