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Cytotoxic susceptibility and defective MHC class I expression do not correlate with mutation of p53 in human carcinomas

✍ Scribed by Zsuzsa Végh; Ping Wang; Farkas Vánky; Christina Hising; Kerstin Sjöwall; Barbro Larsson; Eva Klein


Book ID
105227482
Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
343 KB
Volume
38
Category
Article
ISSN
0340-7004

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## Abstract ## Background. The p53 protein, a well‐known tumor suppressor that functions primarily as a transcription factor, initiates cell cycle arrest and apoptosis after genotoxic stress. The antiapoptotic regulator Bcl‐2 is a downstream modulator of p53‐induced apoptosis. Loss of function of