Cytotoxic properties of metal-quinone complexes: Role of redox cycling in the toxicities of iron(II) and iron(III) complexes of 2- and 5-hydroxy-1,4-naphthoquinones to isolated rat hepatocytes

Mechanisms of toxicity of 2- and 5-hydro

Mechanisms of toxicity of 2- and 5-hydroxy-1,4-naphthoquinone; absence of a role for redox cycling in the toxicity of 2-hydroxy-1,4-naphthoquinone to isolated hepatocytes

✍ Mary D'Arcy Doherty; Adrian Rodgers; Gerald M. Cohen 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 569 KB

The mechanisms of toxicity to isolated rat hepatocytes of two structurally related naphthoquinones have been studied. Both 5-OH-1,4-naphthoquinone (5-OH-1,4-NQ; juglone) and 2-OH-1,4-naphthoquinone (2-OH-1,4-NQ; lawsone) caused a concentration-dependent cytotoxicity to hepatocytes which was preceded