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Cytotoxic Prenylated Phenolic Compounds from the Twig Bark of Garcinia xanthochymus

✍ Scribed by Quan-Bin Han; Chun-Feng Qiao; Jing-Zheng Song; Nian-Yun Yang; Xin-Wei Cao; Yong Peng; Da-Jian Yang; Shi-Lin Chen; Hong-Xi Xu

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
84 KB
Volume
4
Category
Article
ISSN
1612-1872

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✦ Synopsis

Abstract

Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1–3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6‐tetrahydroxy‐7,8‐diprenylxanthone (4), 1,3,5,6‐tetrahydroxy‐4,7,8‐triprenylxanthone (5), garciniaxanthone E (6), and 6‐prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D‐ and 2D‐NMR as well as HR‐MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA‐MB‐435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.

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