Cytotoxic Pentacyclic Triterpenoids from the Rhizome of Astilbe chinensis

✍ Scribed by Hongxiang Sun; Jianxin Zhang; Yiping Ye; Yuanjiang Pan; Yueao Shen

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 100 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390194

✦ Synopsis

Abstract

Guided by in vitro antineoplastic tests, four cytotoxic pentacyclic triterpenoids, 3__β__‐hydroxyolean‐12‐en‐27‐oic acid (1), 3__β__‐hydroxyurs‐12‐en‐27‐oic acid (2), 3__β__,6__β__‐dihydroxyolean‐12‐en‐27‐oic acid (3), and 3__β__‐acetoxyolean‐12‐en‐27‐oic acid (4) were isolated from the rhizome of Astilbe chinensis. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods including one‐dimensional and two‐dimensional NMR. These compounds showed cytotoxic activities against HO‐8910, Hela and HL60 cell lines. In addition, β‐sitosterol palmitate, daucosterol, and β‐sitosterol have also been isolated.