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Cytotoxic effects of tumour necrosis factor and gamma-interferon on acute myeloid leukaemia blasts

โœ Scribed by Price, G; Brenner, MK; Prentice, HG; Hoffbrand, AV; Newland, AC


Book ID
109835899
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
733 KB
Volume
55
Category
Article
ISSN
0007-0920

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The effects of the tumor necrosis factor (TNF), and a second pleiotropic cytokine interferon-gamma (IFN), were examined in a line of human myeloblastic leukemia cells (ML-1). By itself, TNF causes ML-1 to differentiate along the monocytic pathway. The cells exhibit an increase in Fc receptors and ac