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Cytotoxic Effects of N-Hydroxyparacetamol in Suspensions of Isolated Rat Hepatocytes

✍ Scribed by Holme, Jørn A. ;Wirth, Peter J. ;Dybing, Erik ;Thorgeirsson, Snorri S.

Book ID
114800053
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
629 KB
Volume
51
Category
Article
ISSN
0001-6683

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## Abstract Chloroquine is a synthetic quinoline being used as an antimalaria and antirheumatoid agent. Several cases of hepatotoxicity have been reported with the use of chloroquine. However, the mechanism(s) of its hepatotoxic effect is unknown. The purpose of this study was to investigate the cy