Cytotoxic effect of diphtheria toxin used alone or in combination with other agents on human renal cell carcinoma cell lines

Effects of tumor necrosis factor, alone

Effects of tumor necrosis factor, alone or in combination with topoisomerase-ii-targeted drugs, on human lung cancer cell lines

✍ Giuseppe Giaccone; Chikabumi Kadoyama; Rhoda Maneckjee; David Venzon; Richard B. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 418 KB

## Abstract Tumor necrosis factor α (TNF) exhibits cytotoxic activity on some solid tumors and has been reported to be synergistic with topoisomerase‐II‐targeted antineoplastic agents. A wide range of TNF concentrations (from 10 to 10,000 U/ml) was tested in 9 human lung cancer cell lines (5 small‐