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Cytotoxic effect of 7α-hydroxy-4-cholesten-3-one on HepG2 cells: Hypothetical role of acetaldehyde-modified Δ4-3-ketosteroid-5β-reductase (the 37-kd-liver protein) in the pathogenesis of alcoholic liver injury in the rat

✍ Scribed by Renee C. Lin; Michael J. Fillenwarth; Xiangnan Du

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 159 KB
Volume: 27
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.510270117

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Identification of the 37-kd rat liver pr

Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as Δ 4-3-ketosteroid 5β-reductase

✍ Y Zhu; M J Fillenwarth; D Crabb; L Lumeng; R C Lin 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 352 KB

After alcohol ingestion, ethanol is oxidized to acetal-Acetaldehyde, the first product of alcohol metabolism, is highly reactive. Several proteins have been shown to dehyde in the liver mainly by the action of alcohol dehybe covalently modified by acetaldehyde in vivo. We have drogenase 1 and, on pr