𝔖 Bobbio Scriptorium
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Cytotoxic drugs in an avian urate microcrystal arthritis

✍ Scribed by George L. Floersheim; Kay Brune; Karl Seiler


Publisher
SP Birkhäuser Verlag Basel
Year
1973
Tongue
English
Weight
360 KB
Volume
3
Category
Article
ISSN
1420-908X

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Primary resistance to chemotherapeutic agents is a major problem in the management of advanced cancer. By using oestrogen to modulate the topoisomerase II content of T-47D human breast cancer cells, we show here that cell subpopulations resistant to the topoisomerase-ll-interactive drug VP 16 (etopo