Cytotoxic Drug Resistance Mechanisms Volume 28 || Cell Sensitivity Assays: The MTT Assay
✍ Scribed by Brown, Robert; B�ger-Brown, Uta
- Book ID
- 126489755
- Publisher
- Humana Press
- Year
- 1999
- Weight
- 83 KB
- Category
- Article
- ISBN-13
- 9781592596874
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The -yl]-2,5 diphenyl tetrazolium bromide) assay is based on the conversion of MTT into formazan crystals by living cells, which determines mitochondrial activity. Since for most cell populations the total mitochondrial activity is related to the number of viable cells, this assay is broadly used to
The MTT cell viability assay is widely used in determining drug sensitivity profiles for patients with hematological malignancies and in primary screening of potential chemotherapeutic drugs. Because the multidrug resistance (MDR) phenotype is associated with these malignancies, and since many vital