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Cytotoxic Diterpenes from the Root Tuber of Curcuma wenyujin

✍ Scribed by Wei Huang; Peng Zhang; Ye-Cheng Jin; Qiang Shi; Yi-Yu Cheng; Hai-Bin Qu; Zhong-Jun Ma

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
173 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Bioassay‐guided fractionation of ethanolic extract from the root tuber of Curcuma wenyujin afforded three new diterpenes, curcumrinols A–C (1–3), where 2 is the (14__S__)__‐__epimer of 1. The structures of 1–3 were established on the basis of spectroscopic analysis, mainly NMR and MS. 1–3 were tested in vitro for their cytotoxic activity against the HL‐60 and K562 cancer cells. Among the compounds tested, 1 exhibited medium cytotoxicity against K‐562 and HL60 human cancer cells with IC~50~ values of 11.2 and 3.2β€…ΞΌg/ml, respectively. However, 2 showed only weak activity against the above cancers cells, which suggested that C(14) may be an important position for cytotoxic activity.

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✍ Jun-De Chen; Yan Qiu; Zhi-Wei Yang; Peng Lin; Yi-Ming Lin πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 German βš– 165 KB πŸ‘ 1 views

## Abstract Three new dimeric diterpenes, tagalsin L (**1**), tagalsin M (**2**), and tagalsin N (**3**) were isolated from the roots of the mangrove plant __Ceriops tagal.__ Their structures and relative configurations were elucidated by means of extensive IR, NMR, and MS analyses.