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Cytotoxic cholesta-1,4-dien-3-one derivatives from soft coral Nephthea sp.

โœ Scribed by Zhang, Jun; Liao, Xiao-Jian; Wang, Kai-Ling; Deng, Zhou; Xu, Shi-Hai


Book ID
123468976
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
328 KB
Volume
78
Category
Article
ISSN
0039-128X

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1,3-Dienes derived from (R)-4-t-butyldimethylsilyloxy-2-cyclohexen-1-one react with activated dienophiles to form predominately (or sometimes exclusively) syn/endo products. These controlled [4+2] cycloadditions increase the asymmetric complexity from one asymmetric center in the starting material t