Cytotoxic and Apoptotic Effects of Novel Heterodinucleoside Phosphates Consisting of 5-Fluorodeoxyuridine and Ara-C in Human Cancer Cell Lines

The novel heterodinucleoside dimer 5-FdU

The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145

✍ R.M.C. Cattaneo-Pangrazzi; H. Schott; R.A. Schwendener 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB 👁 2 views

BACKGROUND. We analyzed the cytotoxic properties of the new heterodinucleoside phosphate dimer 5-FdU-NOAC, which is composed of the cytotoxic drugs 5-FdU and N 4octadecyl-1-␤-D-arabinofuranosylcytosine (NOAC) against human prostate tumor cells. METHODS. 5-FdU-NOAC effects on cell proliferation, cell