Cytosolic targeting of hen egg lysozyme gives rise to a short-lived protein presented by class I but not class II major histocompatibility complex molecules

Antigen presentation of hen egg-white ly

Antigen presentation of hen egg-white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II-associated invariant chain

✍ Farsin Nadimi; José Moreno; Frank Momburg; Andreas Heuser; Serge Fuchs; Luciano 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 868 KB

The influence of the class II-associated invariant chain (Ii) on the presentation of the protein antigens hen egg-white lysozyme (HEL) and ribonuclease A (RNase) was investigated. For this purpose the Ii- rat-2 fibroblasts were transfected with I-Ak genes with or without Ii. Transfectants expressing