Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia

✍ Scribed by Ran Tao; Yaqin Yu; Xiaojuan Zhang; Yingjun Guo; Jieping Shi; Xuan Zhang; Lin Xie; Shuzheng Liu; Guizhi Ju; Qi Xu; Yan Shen; Jun Wei

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 57 KB
• Volume: 137B
• Category: Article
• ISSN: 1552-4841
• DOI: 10.1002/ajmg.b.30210

✦ Synopsis

The present study detected three single nucleotide polymorphisms (SNPs), BanISNP at the PLA2G4A locus, rs1648833 at the PLA2G4B locus, and rs1549637 at the PLA2G4C locus, to investigate a genetic association between the cytosolic PLA2 (cPLA2) genes and schizophrenia. A total of 240 Chinese parent-offspring trios of Han descent were recruited for the genetic analysis. The transmission disequilibrium test (TDT) showed allelic association for rs1549637 (x 2 ¼ 5.68, uncorrected P ¼ 0.017), but not for BanISNP and rs1648833. The conditioning on genotype (COG) test revealed a disease association for the BanISNP-rs1648833 combination (x 2 ¼ 12.54, df ¼ 3, P ¼ 0.0057) and for the BanISNP-rs1549637 combination (x 2 ¼ 9.72, df ¼ 2, P ¼ 0.021), but the conditioning on allele (COA) test did not show such an association for the above two combinations. Neither the COA test nor the COG showed a disease association for the rs1648833-rs1549637 combination. In the combination of all three SNPs, the COG test, but not the COA test, showed a strong association (x 2 ¼ 22.93, df ¼ 6, P ¼ 0.0008). These findings suggest that these three cPLA2 genes may all be involved in contributing to the etiology of schizophrenia although their effect size appears to be relatively small.